Matrix Restructuring During Liver Regeneration is Regulated by Glycosylation of the Matrix Glycoprotein Vitronectin

There are three major approaches for regenerative medicine. The most innovative approach among them is: induction of target cells from various stem cells such as induced pluripotent stem cells (iPS cells) or embryonic stem cells (ES cells) and implantation of them to regenerate the organ. The second approach is: in vitro tissue regeneration that involves preparation of artificial tissue by combining human cells with scaffolding biomaterials and growth factors. The third is: promotion of self-regeneration through controlling the repair activity of each tissue, which most organisms do naturally, is a more fundamental approach, but it will also be important in cell therapy to regulate tissue organization after induction of differentiation.